Tetraphase Pharmaceuticals
Mar 6, 2014

Tetraphase Reports Fourth-Quarter and Full-Year 2013 Financial Results

WATERTOWN, Mass.--(BUSINESS WIRE)-- Tetraphase Pharmaceuticals, Inc. (NASDAQ:TTPH) today reported financial results for the quarter and full year ended December 31, 2013.

"Our first year as a public company has been a productive one for Tetraphase as we advanced our lead antibiotic candidate, eravacycline, into Phase 3 development and confirmed that we will be pursuing two therapeutic indications for regulatory approval," said Guy Macdonald, Tetraphase President and Chief Executive Officer. "Notably, through our initial public offering and subsequent follow-on offering, we raised approximately $130 million, funding that we believe will support the company through our planned eravacycline regulatory filing in the U.S. by the end of 2015."

Mr. Macdonald added: "Eravacycline is the only antibiotic candidate being studied in both IV and oral formulations for the treatment of multi-drug resistant Gram-negative infections in late-stage clinical trials. Given the increasingly favorable regulatory and legislative environments, and the growing recognition of the rising unmet medical need in the Gram-negative antibiotic space by the scientific, pharmaceutical, investment and media communities, we believe we are well positioned to achieve our near-term corporate objectives. We look forward to reporting on our continued progress throughout the year."

Fourth-Quarter and Full-Year 2013 Financial Results

As of December 31, 2013, Tetraphase had cash and cash equivalents of $102.7 million and 25.6 million shares outstanding.

For the fourth quarter of 2013, Tetraphase reported a net loss of $11.3 million, or $0.49 per share, compared to a net loss of $3.1 million, or $9.43 per share, for the same period in 2012. For the full-year 2013, Tetraphase reported a net loss of $29.6 million, or $1.78 per share, compared to a net loss of $15.1 million or $47.54 per share for the full-year 2012.

Revenues for the fourth quarter of 2013 were $1.9 million compared to $3.2 million for the same period in 2012. Revenues for the full-year 2013 were $10.5 million compared to $7.6 million for the full-year 2012. Revenues for each period consisted of contract and grant revenue under three U.S. government awards for the development of Tetraphase compounds as potential countermeasures for the treatment of diseases caused by bacterial biothreat pathogens. These funds are received through subcontracts and a subaward from CUBRC Inc., an independent, not-for-profit research corporation that specializes in U.S. government-based contracts. These U.S. government awards consist of an award from the Biomedical Advanced Research and Development Authority (BARDA) for eravacycline development and two awards from the National Institute of Allergy and Infectious Diseases (NIAID) for the development of the company's preclinical compound TP-271. The decrease in revenue during the fourth quarter of 2013 compared to the same period in 2012 and the increase during the full-year 2013 compared to the same period in 2012 were primarily due to the timing and scope of activities conducted during the periods under our subcontracts under the BARDA contract.

Research and development (R&D) expenses for the fourth quarter of 2013 were $10.5 million, compared to $4.8 million for the same period in 2012. R&D expenses for the full-year 2013 were $31.5 million compared to $17.3 million for the full-year 2012. The increase in R&D expense during both the fourth quarter of 2013 and full-year 2013 compared to the same periods in the prior year was primarily due to an increase in expenses related to clinical and drug manufacturing costs associated with our ongoing Phase 3 program for eravacycline.

General and administrative (G&A) expenses for the fourth quarter of 2013 were $2.3 million, compared to $1.2 million for the same period in 2012. G&A expenses for the full-year 2013 were $7.2 million compared to $4.3 million for the full-year 2012. This increase in G&A expense during both the fourth quarter of 2013 and full-year 2013 compared to the same periods in the prior year was primarily due to an increase in various general costs due to operating as a public company, as well as an increase in personnel-related costs.

2013 and Recent Corporate Highlights

Eravacycline

Pipeline and Technology

Corporate

About Tetraphase Pharmaceuticals, Inc.

Tetraphase is a clinical-stage biopharmaceutical company using its proprietary chemistry technology to create novel antibiotics for serious and life-threatening multidrug-resistant (MDR) bacterial infections, including many of the MDR Gram-negative bacteria highlighted as urgent public health threats by the Centers for Disease Control and Prevention (CDC). Tetraphase's lead product candidate, eravacycline, is a fully synthetic tetracycline derivative being studied in a Phase 3 clinical program called IGNITE (Investigating Gram-negative Infections Treated with Eravacycline) as a broad-spectrum intravenous and oral antibiotic for use as a first-line empiric monotherapy. Tetraphase has created more than 3,000 novel tetracycline analogs using its technology platform; in addition to eravacycline, Tetraphase has generated multiple preclinical antibiotic candidates that are currently being evaluated for clinical suitability. Please visit www.tphase.com for more company information.

Forward-Looking Statements

Any statements in this press release about our future expectations, plans and prospects, including statements regarding our strategy, future operations, prospects, plans and objectives, and other statements containing the words "anticipates," "believes," "expects," "plans," "will" and similar expressions, constitute forward-looking statements within the meaning of The Private Securities Litigation Reform Act of 1995. Actual results may differ materially from those indicated by such forward-looking statements as a result of various important factors, including: whether our cash resources will be sufficient to fund our continuing operations through the end of 2015; whether results obtained in preclinical studies and early clinical trials will be indicative of results obtained in future clinical trials; whether eravacycline will advance through the clinical trial process on a timely basis and receive approval from the United States Food and Drug Administration or equivalent foreign regulatory agencies; whether, if eravacycline obtains approval, it will be successfully distributed and marketed; and other factors discussed in the "Risk Factors" section of our most recent quarterly report on Form 10-Q, filed with the Securities and Exchange Commission on November 14, 2013. In addition, the forward-looking statements included in this press release represent our views as of March 6, 2014. We anticipate that subsequent events and developments will cause our views to change. However, while we may elect to update these forward-looking statements at some point in the future, we specifically disclaim any obligation to do so.

Tables Follow:

 
Tetraphase Pharmaceuticals, Inc.

Condensed Consolidated Statements of Operations (Unaudited)

(In thousands, except per share data)
           
Three Months Ended Years Ended
December 31, December 31,
2013 2012 2013 2012
 
Revenues $ 1,898   $ 3,240   $ 10,486   $ 7,600  
Operating expenses
Research and development 10,494 4,788 31,508 17,294
General and administrative   2,327     1,154     7,168     4,309  
Total operating expenses   12,821     5,942     38,676     21,603  
Loss from operations   (10,923 )   (2,702 )   (28,190 )   (14,003 )
Other income (expense)
Interest income 5 10
Interest expense (385 ) (369 ) (1,719 ) (1,021 )
Other income (expense)       19     263     (63 )
Other expense, net   (380 )   (350 )   (1,446 )   (1,084 )
Net loss $ (11,303 ) $ (3,052 ) $ (29,636 ) $ (15,087 )

Net loss per share applicable to common

stockholders-basic and diluted

$ (0.49 ) $ (9.43 ) $ (1.78 ) $ (47.54 )

Weighted-average number of common shares

used in net loss per share applicable to common

stockholders-basic and diluted

  23,282     324     16,665     317  
 
 
Tetraphase Pharmaceuticals, Inc.

Condensed Consolidated Balance Sheets (Unaudited)

(In thousands)
      December 31,   December 31,
2013 2012
 
Assets
Cash and cash equivalents $ 102,712 $ 9,079
Accounts receivable 1,706 2,452
Prepaid expenses and other current assets 1,002 850
Property and equipment, net 235 235
Other assets, noncurrent   231   1,456  
Total assets $ 105,886 $ 14,072  
 
Liabilities and stockholders' equity (deficit)
Accounts payable and accrued expenses $ 7,171 $ 4,321
Total term loan 10,815 11,650
Total deferred revenue 92 699
Warrant liability - 610
Convertible preferred stock - 79,841
Stockholder's equity (deficit)   87,808   (83,049 )
Total liabilities and stockholders' equity (deficit) $ 105,886 $ 14,072  
 

Investors:
Tetraphase Pharmaceuticals
Jennifer LaVin, 617-715-3591
Executive Director, Corp. Communications
jlavin@tphase.com
or
Argot Partners
Susan Kim, 212-600-1902
susan@argotpartners.com
or
Media:
Sam Brown Inc.
Mike Beyer, 773-463-4211
beyer@sambrown.com

Source: Tetraphase Pharmaceuticals, Inc.

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