Tetraphase Pharmaceuticals
May 4, 2017

Tetraphase Pharmaceuticals Reports First Quarter 2017 Financial Results and Reviews Recent Highlights

WATERTOWN, Mass., May 04, 2017 (GLOBE NEWSWIRE) -- Tetraphase Pharmaceuticals, Inc. (NASDAQ:TTPH), a clinical-stage biopharmaceutical company developing novel antibiotics to treat life-threatening multidrug-resistant (MDR) infections, today reported financial results for the first quarter ended March 31, 2017 and provided an overview of recent achievements.

"We have continued to make significant advancements across all of our development programs, particularly for IV eravacycline with the early completion of enrollment of IGNITE4 in complicated intra-abdominal infections (cIAI), and the initiation of IGNITE3 in complicated urinary tract infections (cUTI), for which enrollment is progressing well," said Guy Macdonald, President and Chief Executive Officer of Tetraphase.  "Preparations are ongoing for the submission of a Marketing Authorization Application (MAA) to the European Medicines Agency (EMA) for the treatment of cIAI in the third quarter of this year and we look forward to top-line data from IGNITE4 also in the third quarter, which would support a subsequent U.S. New Drug Application (NDA) filing."

Mr. Macdonald added, "We also look forward to data from the ongoing phase 1 clinical trials for oral eravacycline which are designed to optimize the oral dosing regimen, and we continue to anticipate providing an update on that program during the third quarter of 2017."

First Quarter and Recent Highlights

First-Quarter 2017 Financial Results

As of March 31, 2017, Tetraphase had cash and cash equivalents of $128.2 million and 37.7 million shares outstanding.  The company expects that its cash and cash equivalents, as well as expected revenue from its U.S. government awards, will be sufficient to fund operations into the second half of 2018.

Revenues during the first quarter of 2017 were $1.5 million compared to $2.0 million for the same period in 2016.  Revenues for each period consisted of contract and grant revenue under the Company's U.S. government awards for the development of Tetraphase compounds for the treatment of diseases caused by bacterial biothreat pathogens and for certain infections caused by life-threatening multidrug-resistant bacteria. This decrease was primarily due to the scope and timing of activities related to our BARDA subcontract conducted during the quarter ended March 31, 2017, offset in part by an increase in clinical development activities under our NIAID subcontract.

Research and development (R&D) expenses for the first quarter of 2017 were $25.9 million compared to $13.5 million for the same period in 2016. The increase in R&D expenses was primarily due to increased costs related to our IGNITE3 and IGNITE4 phase 3 clinical studies for eravacycline.

General and administrative (G&A) expenses for the first quarter of 2017 were $5.1 million compared to $5.3 million for the same period in 2016.

For the first quarter of 2017, Tetraphase reported a net loss of $29.5 million, or $0.79 per share, compared to a net loss of $16.7 million, or $0.46 per share, for the same period in 2016.

About Tetraphase Pharmaceuticals, Inc.
Tetraphase is a clinical-stage biopharmaceutical company using its proprietary chemistry technology to create novel antibiotics for serious and life-threatening bacterial infections, including those caused by many of the multidrug-resistant (MDR) bacteria highlighted as urgent public health threats by the CDC. Tetraphase has created more than 3,000 novel tetracycline analogs using its proprietary technology platform. Tetraphase's pipeline includes three antibiotic clinical candidates: eravacycline, which is in phase 3 clinical trials, and TP-271 and TP-6076, which are in phase 1 clinical trials. Please visit www.tphase.com for more company information.

Forward-Looking Statements
Any statements in this press release about our future expectations, plans and prospects, including statements regarding our strategy, future operations, prospects, plans and objectives, and other statements containing the words "anticipates," "believes," "expects," "plans," "will" and similar expressions, constitute forward-looking statements within the meaning of The Private Securities Litigation Reform Act of 1995. Actual results may differ materially from those indicated by such forward-looking statements as a result of various important factors, including: whether results obtained in previous clinical trials will be indicative of results obtained in future clinical trials; whether eravacycline or any other clinical candidate will advance through the clinical trial process on a timely basis or at all; whether the results of the Company's development efforts will warrant regulatory submission and whether any such submissions will receive approval from the United States Food and Drug Administration or equivalent foreign regulatory agencies; whether, if any clinical candidate obtains approval, it will be successfully distributed and marketed; and other factors discussed in the "Risk Factors" section of our quarterly report on Form 10-K, filed with the Securities and Exchange Commission on March 13, 2017. In addition, the forward-looking statements included in this press release represent our views as of May 4, 2017. We anticipate that subsequent events and developments will cause our views to change. However, while we may elect to update these forward-looking statements at some point in the future, we specifically disclaim any obligation to do so.

Tetraphase Pharmaceuticals, Inc.
Condensed Consolidated Statement of Operations (Unaudited)
(In thousands, except per share data)
      
 Three Months Ended  
 March 31,  
  2017   2016   
      
Revenues$  1,485  $  1,962   
Operating expenses     
Research and development 25,947   13,523   
General and administrative 5,133     5,253   
Total operating expenses 31,080   18,776   
Loss from operations (29,595)  (16,814)  
Other income (expense)     
Other income (expense), net 137   73   
Net loss$  (29,458) $  (16,741)  
Net loss per share-basic and diluted$  (0.79) $  (0.46)  
Weighted-average number of common shares used in net loss per share     
applicable to common     
stockholders-basic and diluted 37,093   36,598   


Tetraphase Pharmaceuticals, Inc.
Condensed Consolidated Balance Sheets  (unaudited)
(In thousands)
 
 March 31, December 31,
   2017  2016
Assets    
Cash and cash equivalents$128,159 $142,086
Accounts receivable 1,703  1,789
Prepaid expenses and other current assets 3,829  6,582
Property and equipment, net 1,467  1,054
Other assets, noncurrent 199  199
Total assets$ 135,357 $151,710
    
Liabilities and Stockholders' equity     
Accounts payable and accrued expenses$15,366 $10,240
Total deferred revenue 851  1,255
Other liabilities, noncurrent 148  162
Total stockholders' equity 118,992  140,053
Total liabilities and stockholders' equity$135,357 $151,710


Investor Contacts:

Tetraphase Pharmaceuticals

Teri Dahlman

617-600-7040

tdahlman@tphase.com



Argot Partners

Maeve Conneighton

206.899.4940

maeve@argotpartners.com



Media Contact:

Sam Brown Inc.

Mike Beyer

312-961-2502

Mikebeyer@sambrown.com

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Source: Tetraphase Pharmaceuticals

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